Oleuropein

Oleo europa, yani zeytin ağacının yaprağının, antioksidan, antimikrobiyal, antivirütik, antienflamatuar, antikanserojenik, nöroprotektif, antiaterosklerotik, antidiyabetik, hepatoprotektif, antiaritmik etkileri olan bir sekoiridoit fenol bileşene sahip olduğu farmakolojik ve klinik çalışmalar ile gösterilmiştir. ayrıca bağırsak düz kası üzerinde spazmolitik etkisi vardır. Renal koruyucu etkisi ile ilgili çalışmalar mevcuttur.

 

1. albicans, S. aureus, P.aeruginosa gibi gram(+), gram(-) bakteri ve fungus türleri üzerindeki etkileri ile ilgili bilimsel araştırmalar mevcuttur.

HbA1C, serum glukoz, trigliserid, kolesterol ve LDL üzerinde olumlu etkileri mevcuttur. LDL oksidasyonunu engelleyerek kardiyoprotektif özelliklerini sergiler. 

Serbest radikaller önleyici etkisi sayesinde akciğer inflamatuar hastalıklarını önleyici etkisi mevcuttur. Serbest radikalleri süpürücü özelliği; lipooksijenazlar gibi çeşitli inflamatuar enzimleri inhibe ederek,  serbest  radikal üretim reaksiyonlarını kataliz eden Fe ve Cu gibi metal iyonlarını şelatlama özelliği sayesindedir. bu molekül güçlü bir antioksidandır.

Meme Ca, mesane Ca , nöroblastoma tedavilerinde kullanılmakta ve bilimsel yayınlar hızla yayınlanmaya devam etmektedir. 

Antivirütik olarak kullanılmaktadır. antidiyabetik araştırmalar ile yüz güldürücü sonuçlar alınmaktadır. Deneysel olarak 1000 mg/kg gibi dozlarda bile herhangi bir yan etkiye rastlanmamıştır.

Akdeniz havzasının doğal bir bitkisi olan zeytinin türkiye üretici ülkesi konumundadır.

 

Oleuropein, unexpected benefits!

Sun W, Frost B, Liu J.

Oncotarget. 2017 Mar 14;8(11):17409. doi: 10.18632/oncotarget.15538.

PMID: 28407695 

 

Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome.

Ahamad J, Toufeeq I, Khan MA, Ameen MSM, Anwer ET, Uthirapathy S, Mir SR, Ahmad J.

Phytother Res. 2019 Dec;33(12):3112-3128. doi: 10.1002/ptr.6511. Epub 2019 Nov 20.

PMID: 31746508 

 

Oleuropein: Molecular Dynamics and Computation.

Gentile L, Uccella NA, Sivakumar G.

Curr Med Chem. 2017;24(39):4315-4328. doi: 10.2174/0929867324666170912102623.

PMID: 28901273 

 

Anticancer effects of oleuropein.

Shamshoum H, Vlavcheski F, Tsiani E.

Biofactors. 2017 Jul 8;43(4):517-528. doi: 10.1002/biof.1366. Epub 2017 Jun 14.

PMID: 28612982 

 

Oleuropein Mediated Targeting of Signaling Network in Cancer.

Fayyaz S, Aydin T, Cakir A, Gasparri ML, Panici PB, Farooqi AA.

Curr Top Med Chem. 2016;16(22):2477-83. doi: 10.2174/1568026616666160212123706.

PMID: 26873189 

 

Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates.

Imran M, Nadeem M, Gilani SA, Khan S, Sajid MW, Amir RM.

J Food Sci. 2018 Jul;83(7):1781-1791. doi: 10.1111/1750-3841.14198. Epub 2018 Jun 21.

PMID: 29928786 

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Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits.

Al-Azzawie HF, Alhamdani MS.

Life Sci. 2006 Feb 16;78(12):1371-7. doi: 10.1016/j.lfs.2005.07.029. Epub 2005 Oct 19.

PMID: 16236331

 

 

Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats.

Çömez MS, Cellat M, Özkan H, Borazan Y, Aydın T, Gökçek İ, Türk E, Güvenç M, Çakır A, Özsoy ŞY.

Naunyn Schmiedebergs Arch Pharmacol. 2020 Sep;393(9):1691-1699. doi: 10.1007/s00210-020-01870-w. Epub 2020 May 7.

PMID: 32383030

 

Antitumor Perspectives of Oleuropein.

Moran JM, Leal-Hernandez O, Roncero-Martin R, Pedrera-Zamorano JD.

J Food Sci. 2019 Mar;84(3):384. doi: 10.1111/1750-3841.14495.

PMID: 30821855 

 

Oleuropein inhibits esophageal cancer through hypoxic suppression of BTG3 mRNA.

Zhang F , Zhang M .

Food Funct. 2019 Feb 20;10(2):978-985. doi: 10.1039/c8fo02223b.

PMID: 30702111

 

The effect of oleuropein on apoptotic pathway regulators in breast cancer cells.

Asgharzade S, Sheikhshabani SH, Ghasempour E, Heidari R, Rahmati S, Mohammadi M, Jazaeri A, Amini-Farsani Z.

Eur J Pharmacol. 2020 Nov 5;886:173509. doi: 10.1016/j.ejphar.2020.173509. Epub 2020 Sep 2.

PMID: 32889065

 

Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases.

Leto G, Flandina C, Crescimanno M, Giammanco M, Sepporta MV.

Life Sci. 2021 Jan 1;264:118694. doi: 10.1016/j.lfs.2020.118694. Epub 2020 Oct 30.

PMID: 33130080 

 

Antioxidant Effects of Oleuropein on Hydrogen Peroxide-Induced Neuronal Stress- An In Vitro Study.

Kucukgul A, Isgor MM, Duzguner V, Atabay MN, Kucukgul A.

Antiinflamm Antiallergy Agents Med Chem. 2020;19(1):74-84. doi: 10.2174/1871523018666190201145824.

PMID: 30714532

 

Potential Therapeutic Effects of Oleuropein Aglycone in Alzheimer’s Disease.

Martorell M, Forman K, Castro N, Capó X, Tejada S, Sureda A.

Curr Pharm Biotechnol. 2016;17(11):994-1001. doi: 10.2174/1389201017666160725120656.

PMID: 27455905 

 

Oleuropein promotes hippocampal LTP via intracellular calcium mobilization and Ca(2+)-permeable AMPA receptor surface recruitment.

Wang M, Ramasamy VS, Kang HK, Jo J.

Neuropharmacology. 2020 Oct 1;176:108196. doi: 10.1016/j.neuropharm.2020.108196. Epub 2020 Jun 26.

PMID: 32598912

 

Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice.

Jemai H, Mahmoudi A, Feryeni A, Fki I, Bouallagui Z, Choura S, Chamkha M, Sayadi S.

Biomed Res Int. 2020 Apr 3;2020:4398924. doi: 10.1155/2020/4398924. eCollection 2020.

PMID: 32337247 

 

leuropein suppresses oxidative, inflammatory, and apoptotic responses following glycerol-induced acute kidney injury in rats.

Yin M, Jiang N, Guo L, Ni Z, Al-Brakati AY, Othman MS, Abdel Moneim AE, Kassab RB.

Life Sci. 2019 Sep 1;232:116634. doi: 10.1016/j.lfs.2019.116634. Epub 2019 Jul 4.

PMID: 31279782

 

Efficacy and Mechanisms of Oleuropein in Mitigating Diabetes and Diabetes Complications.

Zheng S, Huang K, Tong T.

J Agric Food Chem. 2021 Jun 9;69(22):6145-6155. doi: 10.1021/acs.jafc.1c01404. Epub 2021 May 27.

PMID: 34042426 

 

Antifungal Activity of Oleuropein against Candida albicans-The In Vitro Study.

Zorić N, Kopjar N, Bobnjarić I, Horvat I, Tomić S, Kosalec I.

Molecules. 2016 Nov 28;21(12):1631. doi: 10.3390/molecules21121631.

PMID: 27916806 

 

Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study.

Ahmadvand H, Shahsavari G, Tavafi M, Bagheri S, Moradkhani MR, Kkorramabadi RM, Khosravi P, Jafari M, Zahabi K, Eftekhar R, Soleimaninejad M, Moghadam S.

J Nephropathol. 2017 Jul;6(3):204-209. doi: 10.15171/jnp.2017.34. Epub 2017 Feb 20.

PMID: 28975102 

 

Neuroprotective effect of oleuropein following spinal cord injury in rats.

Khalatbary AR, Ahmadvand H.

Neurol Res. 2012 Jan;34(1):44-51. doi: 10.1179/1743132811Y.0000000058.

PMID: 22196861

 

Oleuropein Curtails Pulmonary Inflammation and Tissue Destruction in Models of Experimental Asthma and Emphysema.

Kim YH, Choi YJ, Kang MK, Lee EJ, Kim DY, Oh H, Kang YH.

J Agric Food Chem. 2018 Jul 25;66(29):7643-7654. doi: 10.1021/acs.jafc.8b01808. Epub 2018 Jul 11.

PMID: 29945446

 

Oleuropein modulates glioblastoma miRNA pattern different from Olea europaea leaf extract.

Tezcan G, Aksoy SA, Tunca B, Bekar A, Mutlu M, Cecener G, Egeli U, Kocaeli H, Demirci H, Taskapilioglu MO.

Hum Exp Toxicol. 2019 Sep;38(9):1102-1110. doi: 10.1177/0960327119855123. Epub 2019 Jun 6.

PMID: 31169033

 

Effects of the olive-derived polyphenol oleuropein on human health.

Barbaro B, Toietta G, Maggio R, Arciello M, Tarocchi M, Galli A, Balsano C.

Int J Mol Sci. 2014 Oct 14;15(10):18508-24. doi: 10.3390/ijms151018508.

PMID: 25318054